Structure of PDB 6f1k Chain A Binding Site BS01

Receptor Information

>6f1k Chain A (length=119) Species: 9606 (Homo sapiens)

KAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWED
REKFEKVPGKYDMLQMDYA

Ligand information

>6f1k Chain C (length=20)

gcctagctacgtagctaggc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6f1k Structural basis for DNA break recognition by ARTD2/PARP2.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): Y132 W151 K179 K183
• Binding residue (residue number reindexed from 1): Y42 W61 K89 K93

Enzymatic activity

• Enzyme Commision number: 2.4.2.-
  2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

• PDB: RCSB:6f1k, PDBe:6f1k, PDBj:6f1k
• PDBsum: 6f1k
• PubMed: 30321391
• UniProt: Q9UGN5|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)