Structure of PDB 6exv Chain A Binding Site BS01

Receptor Information
>6exv Chain A (length=1428) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEHGGCG
RYQPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYAR
PEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNE
QNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLK
GKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIV
TPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGY
KVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNA
DFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTA
VRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSL
IIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKS
LGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIA
DSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRI
LNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVE
GKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGR
EGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGED
GLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLS
NAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIF
HINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIH
LRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQS
LGEPATQMTLNTFHYKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSAR
DAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEM
PDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFND
DNAEKLVLRIRIMNSDENKMDDDVFLRCIESNMLTDMTLQGIEQISKVYM
HLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTS
NDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRG
HLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIM
LGQLAPAGTGCFDLLLDAEKCKYGMEIP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6exv Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		N742 R749 S782 Q783 V788 G789 Q790 Q791 N792 H839 G842 E845 H1108
Binding residue
(residue number reindexed from 1)		N698 R705 S738 Q739 V744 G745 Q746 Q747 N748 H795 G798 E801 H1064
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6exv, PDBe:6exv, PDBj:6exv
PDBsum6exv
PubMed29550768
UniProtI3LJR4

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