Structure of PDB 6eu0 Chain A Binding Site BS01

Receptor Information
>6eu0 Chain A (length=1421) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKA
NGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATI
QILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKK
QRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGE
WKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPS
GRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPVKPIRGFCQRLKGKQG
RFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYN
RHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVV
ERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADF
DGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSY
LISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSL
LIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSG
VMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSI
GINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTL
EAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAV
VGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFL
FHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIV
QFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMET
ANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYI
NGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRI
SEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFSMN
VTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSD
VAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQ
ASDVNIIGKDRIAINDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDG
KRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREI
NYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASF
EKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEK
DLVPKRCLFESLSNEAALKAN
Ligand information
>6eu0 Chain R (length=51) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttttcggctactataaaaaaatgtttttttcgttcgcgaagtaacccttc
g
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eu0 Structural basis of RNA polymerase III transcription initiation.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		K165 K1134 V1135 F1374
Binding residue
(residue number reindexed from 1)		K165 K1116 V1117 F1335
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eu0, PDBe:6eu0, PDBj:6eu0
PDBsum6eu0
PubMed29345637
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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