Structure of PDB 6erh Chain A Binding Site BS01

Receptor Information
>6erh Chain A (length=490) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRDSLIFLVDASKAMFESDELTPFDMSIQCIQSVYISKIISSDRDLLAVV
FYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMG
HGSDYSLSEVLWVCANLFSDSHKRIMLFTNEDNPHGNDSAKASRARTKAG
DLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDRVHFEESSKLEDLLR
KVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNE
PVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPG
LMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEV
AALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKR
KMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALA
LDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDY
Ligand information
Receptor-Ligand Complex Structure
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PDB6erh XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R254 A255 L256 S257 R258 R403 R444
Binding residue
(residue number reindexed from 1)		R210 A211 L212 S213 R214 R359 R400
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erh, PDBe:6erh, PDBj:6erh
PDBsum6erh
PubMed30291363
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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