Structure of PDB 6eop Chain A Binding Site BS01

Receptor Information
>6eop Chain A (length=841) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD
RIYYLAMSNRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQYSREEELLR
ERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNL
VETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNEL
ANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEEN
DESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRI
IDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVL
ISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVF
PQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKC
PIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVS
YVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPE
DDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDL
QPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRG
SCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSY
GGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGY
YLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYD
LQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6eop Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		M76 R160 E275 E276 Y669 W754 S755 Y756 V781 W784 Y787 Y791 H865 S866 I867 G873 Y876 E877
Binding residue
(residue number reindexed from 1)		M29 R104 E219 E220 Y613 W698 S699 Y700 V725 W728 Y731 Y735 H809 S810 I811 G817 Y820 E821
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y613 S699 Y700 D777 H809
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6eop, PDBe:6eop, PDBj:6eop
PDBsum6eop
PubMed29382749
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

[Back to BioLiP]