Structure of PDB 6el7 Chain A Binding Site BS01
Receptor Information
>6el7 Chain A (length=247) Species:
9606
(Homo sapiens) [
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PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQALFDEIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
Ligand information
>6el7 Chain B (length=13) Species:
9606
(Homo sapiens) [
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ENALLRYLLDKDD
Receptor-Ligand Complex Structure
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PDB
6el7
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
Resolution
2.18 Å
Binding residue
(original residue number in PDB)
V575 K579 R585 L589 M593 Q597 E751 M752 E755 N759
Binding residue
(residue number reindexed from 1)
V46 K50 R56 L60 M64 Q68 E222 M223 E226 N230
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6el7
,
PDBe:6el7
,
PDBj:6el7
PDBsum
6el7
PubMed
29424542
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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