Structure of PDB 6ejw Chain A Binding Site BS01

Receptor Information

>6ejw Chain A (length=101) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTR
VRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVL
L

Ligand information

InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)

SEOVTRFCIGRIMH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.6	c1ccc2c(c1)c(c[nH]2)CC(=O)O
ACDLabs 12.01	O=C(O)Cc2c1ccccc1nc2
CACTVS 3.370	OC(=O)Cc1c[nH]c2ccccc12

Formula

C10 H9 N O2

Name

1H-INDOL-3-YLACETIC ACID;
INDOLE ACETIC ACID

ZINC000000083860

PDB chain

6ejw Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	6ejw Auxin Sensor based on the Tryptophan Repressor TrpR
Resolution	1.99 Å
Binding residue (original residue number in PDB)	R54 I57 T81 R84 G85
Binding residue (residue number reindexed from 1)	R50 I53 T77 R80 G81
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0045892	negative regulation of DNA-templated transcription

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:6ejw, PDBe:6ejw, PDBj:6ejw
PDBsum	6ejw
PubMed
UniProt	P0A881\|TRPR_ECOLI Trp operon repressor (Gene Name=trpR)

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