Structure of PDB 6eje Chain A Binding Site BS01

Receptor Information
>6eje Chain A (length=695) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCP
LEGKANKNSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYI
HVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDL
LEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARF
IRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTF
STDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRK
LGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEI
IGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARL
GLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLA
VSKLETLETWVMPKKVFKIFGRLQFSEVGTDWDAKERLFRNFGGLLGPMD
EPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNL
PLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLR
NAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMW
TAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eje Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		H451 K461 Q462 S493 E529 W555 R557 W571 C572 G573
Binding residue
(residue number reindexed from 1)		H193 K203 Q204 S235 E271 W297 R299 W313 C314 G315
Enzymatic activity
Enzyme Commision number 2.4.2.26: protein xylosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0030166 proteoglycan biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eje, PDBe:6eje, PDBj:6eje
PDBsum6eje
PubMed29681470
UniProtQ86Y38|XYLT1_HUMAN Xylosyltransferase 1 (Gene Name=XYLT1)

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