Structure of PDB 6ejc Chain A Binding Site BS01

Receptor Information
>6ejc Chain A (length=701) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCP
LEGKANKQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDH
FYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQS
MRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRD
NARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVE
YVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITN
WNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVV
NQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHS
FARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHA
TNLAVSKLETLETWVMPKKVFKIADFGRLQFSEVGTDWDAKERLFRNFGG
LLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHY
KPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKL
HNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDS
LVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRL
R
Ligand information
Receptor-Ligand Complex Structure
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PDB6ejc Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.
Resolution2.057 Å
Binding residue
(original residue number in PDB)		K461 Q462 R466 S493 E529 T553 W555 W571 C572 G573 C574
Binding residue
(residue number reindexed from 1)		K207 Q208 R212 S239 E275 T299 W301 W317 C318 G319 C320
Enzymatic activity
Enzyme Commision number 2.4.2.26: protein xylosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0030166 proteoglycan biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ejc, PDBe:6ejc, PDBj:6ejc
PDBsum6ejc
PubMed29681470
UniProtQ86Y38|XYLT1_HUMAN Xylosyltransferase 1 (Gene Name=XYLT1)

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