Structure of PDB 6ej8 Chain A Binding Site BS01

Receptor Information
>6ej8 Chain A (length=703) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFC
PLEGKANKNQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHK
DHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYL
QSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHG
RDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRF
VEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRI
TNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEA
VVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLY
HSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKH
HATNLAVSKLETLETWVMPKKVFKIASPGRLQFSEVGTDWDAKERLFRNF
GGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFT
HYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEAL
KLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWL
DSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDG
RLR
Ligand information
Receptor-Ligand Complex Structure
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PDB6ej8 Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		H451 K461 Q462 S493 E529 W555 R557 W571 C572 G573 C574
Binding residue
(residue number reindexed from 1)		H199 K209 Q210 S241 E277 W303 R305 W319 C320 G321 C322
Enzymatic activity
Enzyme Commision number 2.4.2.26: protein xylosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0030166 proteoglycan biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ej8, PDBe:6ej8, PDBj:6ej8
PDBsum6ej8
PubMed29681470
UniProtQ86Y38|XYLT1_HUMAN Xylosyltransferase 1 (Gene Name=XYLT1)

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