Structure of PDB 6ej7 Chain A Binding Site BS01

Receptor Information

>6ej7 Chain A (length=706) Species: 9606 (Homo sapiens)

DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFC
PLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYH
KDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTY
LQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSH
GRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRR
FVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLR
ITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFE
AVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTL
YHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIK
HHATNLAVSKLETLETWVMPKKVFKIASPDFGRLQFSEVGTDWDAKERLF
RNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTA
EFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPE
EALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALE
GWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVK
PDGRLR

Ligand information

>6ej7 Chain B (length=10) Species: 9606 (Homo sapiens)

EEEGAGGGQG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ej7 Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): H451 K461 Q462 R466 R477 E529 W555 R557 W571 C572 G573 C574
• Binding residue (residue number reindexed from 1): H200 K210 Q211 R215 R226 E278 W304 R306 W320 C321 G322 C323

Enzymatic activity

• Enzyme Commision number: 2.4.2.26: protein xylosyltransferase.

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity
• GO:0030158 protein xylosyltransferase activity

Biological Process

• GO:0030166 proteoglycan biosynthetic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6ej7, PDBe:6ej7, PDBj:6ej7
• PDBsum: 6ej7
• PubMed: 29681470
• UniProt: Q86Y38|XYLT1_HUMAN Xylosyltransferase 1 (Gene Name=XYLT1)