Structure of PDB 6e7i Chain A Binding Site BS01

Receptor Information

>6e7i Chain A (length=494) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHD
QCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILV
DDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLD
SHCECNEHWLEPLLERVAEDRTRVVSPIADVINMDNFQYVGASADLKGGF
DWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGAFVMDKFYFEELGKY
DMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSG
TVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCK
PFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECH
NAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQ
IEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN

Ligand information

>6e7i Chain P (length=9) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

STTPAPTTK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6e7i Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	G265 A266 S267 F280 W282 W331 R356 F361 R362 K363 Q364 H365
Binding residue (residue number reindexed from 1)	G191 A192 S193 F206 W208 W257 R282 F287 R288 K289 Q290 H291

Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

External links

PDB	RCSB:6e7i, PDBe:6e7i, PDBj:6e7i
PDBsum	6e7i
PubMed	32325029
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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