Structure of PDB 6e53 Chain A Binding Site BS01

Receptor Information

>6e53 Chain A (length=596) Species: 7070 (Tribolium castaneum)

MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILA
LLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAI
PWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIR
KEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIF
PDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKV
DIRDAYGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIY
KWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSP
HPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQ
VRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTK
FEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLV
LSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEI
YKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFVKINRKASI

Ligand information

>6e53 Chain E (length=23)

cugaccugacttcggtcaggtca

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6e53 A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): S198 I199 K210 Y217 G309 P311 D344 G391 K406 K416 F417 K418 N421 N423 P442 F443 C445 N446 K477
• Binding residue (residue number reindexed from 1): S198 I199 K210 Y217 G309 P311 D344 G391 K406 K416 F417 K418 N421 N423 P442 F443 C445 N446 K477

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:6e53, PDBe:6e53, PDBj:6e53
• PDBsum: 6e53
• PubMed: 30951520
• UniProt: Q0QHL8