Structure of PDB 6e37 Chain A Binding Site BS01

Receptor Information

>6e37 Chain A (length=692) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
HIYDNRIVLNGIDLKAFLDSLPDVKIVNMPVIPMNTIAEAVIEMINRGQI
QITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYC
NFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGL
PQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVT
MPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRG
KVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI

Ligand information

>6e37 Chain B (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSAN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6e37 Targeted covalent inhibition of O-GlcNAc transferase in cells.
Resolution	2.531 Å
Binding residue (original residue number in PDB)	H496 N557 P559 Y632 T633 K634 Q839 V895 P897
Binding residue (residue number reindexed from 1)	H183 N244 P246 Y319 T320 K321 Q504 V560 P562

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:6e37, PDBe:6e37, PDBj:6e37
PDBsum	6e37
PubMed	31626249
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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