Structure of PDB 6e1o Chain A Binding Site BS01

Receptor Information
>6e1o Chain A (length=591) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAA
SKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITV
PKITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTF
GEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVF
IEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIVFPATKRMYRQLLQ
VPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMS
AVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYV
PFASRIVPYLDVFEFSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQR
VFREYKEEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLV
PVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSI
TSSALVYMFSNGHEGPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLE
PPNTRRERIERFMMRKRYLDTFWMRQRGWKESAEVGLSLIT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6e1o Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6e1o Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		E445 D511 E514 D547 K550
Binding residue
(residue number reindexed from 1)		E391 D429 E432 D465 K468
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0017121 plasma membrane phospholipid scrambling
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0070588 calcium ion transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e1o, PDBe:6e1o, PDBj:6e1o
PDBsum6e1o
PubMed30648972
UniProtQ4WA18

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