Structure of PDB 6dvz Chain A Binding Site BS01

Receptor Information
>6dvz Chain A (length=643) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTA
SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYE
GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGET
PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQN
DFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSRE
IKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNID
NRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPR
EDEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQ
SILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLA
YTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSK
DKKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVIL
TFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSR
FRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIR
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain6dvz Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6dvz Structure and gating mechanism of the transient receptor potential channel TRPV3.
Resolution4.24 Å
Binding residue
(original residue number in PDB)		H417 H426 H430 R693
Binding residue
(residue number reindexed from 1)		H303 H312 H316 R579
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dvz, PDBe:6dvz, PDBj:6dvz
PDBsum6dvz
PubMed30127359
UniProtQ8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 (Gene Name=Trpv3)

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