Structure of PDB 6du4 Chain A Binding Site BS01

Receptor Information
>6du4 Chain A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSMHARNRYKDKPPDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRA
LTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHLRRGIDIGT
GASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVP
QKTLLMDALSEIIYDFCMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGG
ITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRI
QGVPKVTYTEFCQGRTMRWALAWSFYDDVTVPSPPSK
Ligand information
>6du4 Chain B (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuggcguaggcuacagagaagccaacc
<<<<<<<...............>>>>>>>
Receptor-Ligand Complex Structure
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PDB6du4 Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		P18 F20 L38 R41 F46 K47 L75 T78 P80 L81 F187 F188 S199 R200 N201 R203 R204 P205 P206 P207 S208 S209 V210 N211 I218 G250 K252 Q277 G278 R279 T280 M281 R282 W283
Binding residue
(residue number reindexed from 1)		P14 F16 L34 R37 F42 K43 L71 T74 P76 L77 F173 F174 S185 R186 N187 R189 R190 P191 P192 P193 S194 S195 V196 N197 I204 G236 K238 Q263 G264 R265 T266 M267 R268 W269
Enzymatic activity
Enzyme Commision number 2.1.1.346: U6 snRNA m(6)A methyltransferase.
2.1.1.348: mRNA m(6)A methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6du4, PDBe:6du4, PDBj:6du4
PDBsum6du4
PubMed30197297
UniProtQ86W50|MET16_HUMAN RNA N6-adenosine-methyltransferase METTL16 (Gene Name=METTL16)

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