Structure of PDB 6dhw Chain A Binding Site BS01

Receptor Information
>6dhw Chain A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLT
LEQALQFWKQFDKGYSYNIRHSFDYTPFSCLKIILSNPPSQGDYHGCPFR
HSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDDC
GFSLNHPNQFFCESQRILNG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6dhw Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6dhw Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.
Resolution2.013 Å
Binding residue
(original residue number in PDB)		P285 C287 C367 I370 C384 F386 Q421 C424 L441 P444
Binding residue
(residue number reindexed from 1)		P16 C18 C80 I83 C97 F99 Q134 C137 L154 P157
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:6dhw, PDBe:6dhw, PDBj:6dhw
PDBsum6dhw
PubMed30562384
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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