Structure of PDB 6d6v Chain A Binding Site BS01

Receptor Information
>6d6v Chain A (length=980) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLT
TTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIG
TTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKV
EQNGYLQVAGVCLNQYFSVQKQENQYIYPEIQRSQIFYCNHMGREPGVFK
SSFFNYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENY
QSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQITNFLRQIIQNC
VPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDL
KNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYNFYITEKHKEGSQ
IFYYRKPIWKLVSKLTIVKLEEFQKYPQGKLRIIPKKGSFRPIMTFLRKD
KQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIE
KWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLL
FQRNKRPLLQIQNFPYYFNLKERQIAYSLYDDDDQILQKGFKEIQSDDRP
FIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNIS
GVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDSQQNAL
NLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYNLEHFKISVQNECQWIG
KSIDMNTLEIKSIQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQL
IDYFNPNINSFEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQ
YGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWI
MWDIIVSYLKKKKQFKGYLNKLLQKIRKSRFFYLKEGCKSLQLILSQQKY
QLNKKELEAIEFIDLNNLIQDIKTLIPKIS
Ligand information
>6d6v Chain B (length=159) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auacccgcuuaauucauucagaucuguaauagaacugucauucaacccca
aaaaucuagugcugauauaaccuucaccaauuagguucaaauaaguggua
augcgggacaaaagacuaucgacauuugauacacuauuuaucaauggaug
ucuuauuuu
...<<<<<..........<<<..<<.....>>..>>>.............
...................(((...<<<<.<<<))).....>>>.>>>>.
..>>>>>.....<<<<.<<<...<<.<<<<.........>>>>>>.>>>>
>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6d6v Structure of Telomerase with Telomeric DNA.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		F178 Q181 N217 Q218 Y231 H234 M235 G236 R237 E238 F242 K243 S244 N324 Y325 L327 K328 K332 L333 Y337 K341 K374 R413 L420 C424 Q444 K445 R446 K447 I449 S450 R453 R473 K497 K501 K532 I545 R550 R573 D589 N590 R655 N691 F696 N697 K699 K762 N776 I909 K910 K913 K917 N918 R921 F924 L969 K971 K973 Q974 Q978 D991 Y994 Y995 E998 K1038 K1041 Q1042 K1044 K1053 R1055 K1056 S1057 F1059 F1060 K1063
Binding residue
(residue number reindexed from 1)		F167 Q170 N174 Q175 Y188 H191 M192 G193 R194 E195 F199 K200 S201 N237 Y238 L240 K241 K245 L246 Y250 K254 K287 R326 L333 C337 Q357 K358 R359 K360 I362 S363 R366 R386 K410 K414 K430 I443 R448 R471 D487 N488 R553 N563 F568 N569 K571 K634 N648 I781 K782 K785 K789 N790 R793 F796 L841 K843 K845 Q846 Q850 D863 Y866 Y867 E870 K910 K913 Q914 K916 K925 R927 K928 S929 F931 F932 K935
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d6v, PDBe:6d6v, PDBj:6d6v
PDBsum6d6v
PubMed29775593
UniProtO77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)

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