Structure of PDB 6d40 Chain A Binding Site BS01

Receptor Information
>6d40 Chain A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSFDCGKPQVEPKKCPVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISP
EWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRK
DIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAG
LLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPL
VCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Ligand information
Receptor-Ligand Complex Structure
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PDB6d40 Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
Resolution1.43 Å
Binding residue
(original residue number in PDB)		F587 H603 D646 R719 S736 C737 Q738 G739 S741 S760 W761 G762 L763
Binding residue
(residue number reindexed from 1)		F42 H58 D101 R174 S191 C192 Q193 G194 S196 S215 W216 G217 L218
Enzymatic activity
Catalytic site (original residue number in PDB) H603 D646 Q738 G739 D740 S741
Catalytic site (residue number reindexed from 1) H58 D101 Q193 G194 D195 S196
Enzyme Commision number 3.4.21.7: plasmin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6d40, PDBe:6d40, PDBj:6d40
PDBsum6d40
PubMed30520638
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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