Structure of PDB 6d3y Chain A Binding Site BS01

Receptor Information
>6d3y Chain A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFDCGKPQVEPKKCPVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPE
WVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKD
IALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGL
LKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLV
CFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Ligand information
Receptor-Ligand Complex Structure
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PDB6d3y Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
Resolution1.32 Å
Binding residue
(original residue number in PDB)		H586 F587 H603 R719 D735 S736 C737 Q738 G739 S741 S760 W761 G762 L763
Binding residue
(residue number reindexed from 1)		H40 F41 H57 R173 D189 S190 C191 Q192 G193 S195 S214 W215 G216 L217
Enzymatic activity
Catalytic site (original residue number in PDB) H603 D646 Q738 G739 D740 S741 G742
Catalytic site (residue number reindexed from 1) H57 D100 Q192 G193 D194 S195 G196
Enzyme Commision number 3.4.21.7: plasmin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6d3y, PDBe:6d3y, PDBj:6d3y
PDBsum6d3y
PubMed30520638
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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