Structure of PDB 6d0m Chain A Binding Site BS01

Receptor Information
>6d0m Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNMNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6d0m Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Resolution1.832 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 I47 I48 R61 S62 K86 R93 K293 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 I50 I51 R64 S65 K89 R96 K291 K309 R311 P314 K315 T316 G318 S320 K321 N322 P324 G325
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6d0m, PDBe:6d0m, PDBj:6d0m
PDBsum6d0m
PubMed30140014
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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