Structure of PDB 6d06 Chain A Binding Site BS01

Receptor Information
>6d06 Chain A (length=384) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDA
KVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLN
NKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEE
PADRHPNRKARGQLRTKIESGYGTIPVRSNASIQTWDGVLQGERLLTMSC
SDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATT
GKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAK
EYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>6d06 Chain B (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcucgcgaugcuggagggcucug
.......................
Receptor-Ligand Complex Structure
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PDB6d06 A Bump-Hole Approach for Directed RNA Editing.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		T375 K376 H394 E396 C451 R455 H460 H471 N473 R474 K475 S486 G487 Y488 C516
Binding residue
(residue number reindexed from 1)		T59 K60 H78 E80 C135 R139 H144 H155 N157 R158 K159 S170 G171 Y172 C200
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6d06, PDBe:6d06, PDBj:6d06
PDBsum6d06
PubMed30581135
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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