Structure of PDB 6cym Chain A Binding Site BS01

Receptor Information
>6cym Chain A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>6cym Chain B (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB6cym Reversible covalent direct thrombin inhibitors.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E22 I23 G24 M25 P27 W28 D127 H130 P131 V132 C133 Y148 K149 R151 N178 M225 K226 P228 R232 W233
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 R137 N157 M204 K205 P207 R211 W212
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D113 E216 G217 D218 S219 G220
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cym, PDBe:6cym, PDBj:6cym
PDBsum6cym
PubMed30071045
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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