Structure of PDB 6cx8 Chain A Binding Site BS01

Receptor Information

>6cx8 Chain A (length=173) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961)

MNSQLTLRALERGDLRFIHNLNNNRNIMSYWFEEPYESFDELEELYNKHI
HDNAERRFVVEDAQKNLIGLVELIEINYIHRSAEFQIIIAPEHQGKGFAR
TLINRALDYSFTILNLHKIYLHVAVENPKAVHLYEECGFVEEGHLVEEFF
INGRYQDVKRMYILQSKYLNRSE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 6cx8 Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6cx8 Crystal structure of spermidine/spermine N-acetyltransferase SpeG from Vibrio cholerae in complex with manganese ions.
• Resolution: 2.41 Å
• Binding residue (original residue number in PDB): E33 E75
• Binding residue (residue number reindexed from 1): E33 E75
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.57: diamine N-acetyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004145 diamine N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0046872 metal ion binding

Biological Process

• GO:0006598 polyamine catabolic process
• GO:0046203 spermidine catabolic process
• GO:0046208 spermine catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6cx8, PDBe:6cx8, PDBj:6cx8
• PDBsum: 6cx8
• UniProt: Q9KL03|ATDA_VIBCH Spermidine N(1)-acetyltransferase (Gene Name=speG)