Structure of PDB 6cvt Chain A Binding Site BS01

Receptor Information
>6cvt Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSL
KAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHG
ISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELL
KLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cvt Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
Resolution2.941 Å
Binding residue
(original residue number in PDB)		W167 Y195 K197 S255 K277
Binding residue
(residue number reindexed from 1)		W4 Y32 K34 S92 K114
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvt, PDBe:6cvt, PDBj:6cvt
PDBsum6cvt
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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