Structure of PDB 6cvr Chain A Binding Site BS01

Receptor Information
>6cvr Chain A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSI
SSLKAVAREHLELLKHMHTVGEKVIVDFAGSNKLRFRLGYHAIPSMSHVH
LHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMP
ELLKLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cvr Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		W167 Y195 K197 S255 K274 K277 H278
Binding residue
(residue number reindexed from 1)		W7 Y35 K37 S95 K114 K117 H118
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvr, PDBe:6cvr, PDBj:6cvr
PDBsum6cvr
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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