Structure of PDB 6cv7 Chain A Binding Site BS01

Receptor Information

>6cv7 Chain A (length=365) Species: 10090 (Mus musculus)

YDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPT
IELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVN
KKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG
DNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNY
EDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP
NTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGI
LYSILVGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNG
HPLPAFASLHIEILD

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6cv7 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6cv7 Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture.
• Resolution: 1.692 Å
• Binding residue (original residue number in PDB): E27 E28 D83 D85 D121
• Binding residue (residue number reindexed from 1): E26 E27 D82 D84 D120
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0007605 sensory perception of sound
• GO:0048839 inner ear development

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032420 stereocilium

External links

• PDB: RCSB:6cv7, PDBe:6cv7, PDBj:6cv7
• PDBsum: 6cv7
• PubMed: 30057206
• UniProt: Q99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)