Structure of PDB 6cta Chain A Binding Site BS01
Receptor Information
>6cta Chain A (length=344) Species:
9606
(Homo sapiens) [
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GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQF
LEGEILSASKMLSKFRKIIKEEINDIDVIMKGGSPAVTLLISEKISVDIT
LALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAQEETWRL
SFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDK
KHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRT
EKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
Ligand information
>6cta Chain B (length=13) [
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cgtcttcggcaat
Receptor-Ligand Complex Structure
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PDB
6cta
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Resolution
2.779 Å
Binding residue
(original residue number in PDB)
S180 A183 N210 Y214 Y215 K384
Binding residue
(residue number reindexed from 1)
S20 A23 N50 Y54 Y55 K207
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:6cta
,
PDBe:6cta
,
PDBj:6cta
PDBsum
6cta
PubMed
30007416
UniProt
Q8N884
|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)
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