Structure of PDB 6ct9 Chain A Binding Site BS01
Receptor Information
>6ct9 Chain A (length=348) Species:
9606
(Homo sapiens) [
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GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIDVIMKGGSPAVTLLISEKISVDI
TLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKGFQEE
TWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKER
FKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQ
CLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
Ligand information
>6ct9 Chain B (length=13) [
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cgtcttcggcaat
Receptor-Ligand Complex Structure
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PDB
6ct9
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Resolution
2.26 Å
Binding residue
(original residue number in PDB)
S180 A183 N210 Y214 Y215 K384
Binding residue
(residue number reindexed from 1)
S20 A23 N50 Y54 Y55 K211
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:6ct9
,
PDBe:6ct9
,
PDBj:6ct9
PDBsum
6ct9
PubMed
30007416
UniProt
Q8N884
|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)
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