Structure of PDB 6crm Chain A Binding Site BS01

Receptor Information
>6crm Chain A (length=512) Species: 290339 (Cronobacter sakazakii ATCC BAA-894) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVYSQETLAKQVLQETFGYQQFRPGQATIIDAVLEGRDCLVVMPTGGGKS
LCYQIPALVKTGLTIVVSPLISLMKDQVDQLLANGVAAACLNSTQSREEQ
QAVLAGCRTGQVRLLYIAPERLMMDNFIDTLGYWDLAMVAVDEAHCISQW
GHDFRPEYAALGQLRARFPAVPFMALTATADDTTRRDIVRLLGLDDPLIE
ISSFDRPNIRYMLMEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTAA
RLQSRGISAAAYHAGLEHEVRASVQEKFQRDDLQIVVATVAFGMGINKPN
VRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAWLRRCLEE
KAPGPLQDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGRQAPCGNCDICL
DPPRRYDGLVDAQKALSAIARVEQRFGMGYVVEVLRGANNQRIRELGHDK
LKVYGIGRDQSQEHWVSVIRQLIHLGVVTQNIAQHSALQLTEAARPFLRG
EAPLMLAVPRVA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6crm A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases.
Resolution2.19286 Å
Binding residue
(original residue number in PDB)		L74 I75 S97 E124 R125 W154 F158 R159 K222 P223 N244 S245 R246 K248 H267 A268 R275 T293 D312 R315 D344 W347 C351 K355
Binding residue
(residue number reindexed from 1)		L70 I71 S93 E120 R121 W150 F154 R155 K218 P219 N240 S241 R242 K244 H263 A264 R271 T289 D308 R311 D340 W343 C347 K351
Binding affinityPDBbind-CN: Kd=4.7uM
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0009432 SOS response

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Molecular Function
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Biological Process
External links
PDB RCSB:6crm, PDBe:6crm, PDBj:6crm
PDBsum6crm
PubMed30305632
UniProtA7MQK9

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