Structure of PDB 6cqr Chain A Binding Site BS01

Receptor Information

>6cqr Chain A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFA
SFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREP
NVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLP
FLPSTEDVYDCRVEHWGLDEPLLKHWEFD

Ligand information

>6cqr Chain C (length=13) Species: 11706 (HIV-1 M:B_HXB2R) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RFYKTLRAEQASQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6cqr CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
Resolution	3.04 Å
Binding residue (original residue number in PDB)	Q9 F22 F32 S53 F54 G58 A61 N62 V65 N69 I72
Binding residue (residue number reindexed from 1)	Q7 F20 F30 S51 F52 G56 A59 N60 V63 N67 I70

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:6cqr, PDBe:6cqr, PDBj:6cqr
PDBsum	6cqr
PubMed	29884618
UniProt	P01903\|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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