Structure of PDB 6cq2 Chain A Binding Site BS01

Receptor Information
>6cq2 Chain A (length=688) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKS
QPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDRE
GEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQE
TRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRS
AAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRK
GDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQE
ASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQL
YGDEYVAPAPRQYTRKVKNAQEHEAIRPAGETFATPDAVRRELDGPNIDD
FRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPG
FLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPAR
YTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAV
TGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVP
DSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYL
ERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cq2 Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.
Resolution3.004 Å
Binding residue
(original residue number in PDB)		E24 S25 P26 R46 G47 H48 R54 K89 E115 R167 R168 D171 R172 G175 Y176 W183 K189 S191 G193 R194 V195 Q196 Y342 R344 R533 S535 T536 R547
Binding residue
(residue number reindexed from 1)		E9 S10 P11 R31 G32 H33 R39 K74 E100 R152 R153 D156 R157 G160 Y161 W168 K174 S176 G178 R179 V180 Q181 Y327 R329 R517 S519 T520 R531
Enzymatic activity
Catalytic site (original residue number in PDB) E24 D111 D113 E115 Y342 R344 H389
Catalytic site (residue number reindexed from 1) E9 D96 D98 E100 Y327 R329 H373
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cq2, PDBe:6cq2, PDBj:6cq2
PDBsum6cq2
PubMed29905859
UniProtP9WG49|TOP1_MYCTU DNA topoisomerase 1 (Gene Name=topA)

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