Structure of PDB 6cnd Chain A Binding Site BS01

Receptor Information
>6cnd Chain A (length=1428) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEW
KEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSG
RPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKA
GLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIR
GFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKV
LTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMK
LAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLN
ECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPII
AATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPY
YLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGF
VIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLC
ARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELE
TQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKG
STLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNS
FFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYD
NTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQD
KGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAE
RDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDN
VKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPM
NVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLS
DVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKI
QASDVNIIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAV
INIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAAR
YSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDS
VLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVK
GTNISEKDLVPKRCLFESLSNEAALKAN
Ligand information
>6cnd Chain Y (length=61) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccatggagtcattttatcttgtgtcacttacagaaaaagtattactaata
tatgttgaaaa
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cnd Structural visualization of RNA polymerase III transcription machineries.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		P338 N342 R378 A880 Y884 R887 E1390 K1391
Binding residue
(residue number reindexed from 1)		P337 N341 R377 A879 Y883 R886 E1358 K1359
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6cnd, PDBe:6cnd, PDBj:6cnd
PDBsum6cnd
PubMed30083386
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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