Structure of PDB 6cko Chain A Binding Site BS01

Receptor Information
>6cko Chain A (length=66) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKN
LTAKKERLQLLNAQLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6cko Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cko Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E737 H764
Binding residue
(residue number reindexed from 1)		E8 H35
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6cko, PDBe:6cko, PDBj:6cko
PDBsum6cko
PubMed29563185
UniProtP55197|AF10_HUMAN Protein AF-10 (Gene Name=MLLT10)

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