Structure of PDB 6cf6 Chain A Binding Site BS01
Receptor Information
>6cf6 Chain A (length=320) Species:
10090
(Mus musculus) [
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ADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKST
PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL
LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA
VDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS
HETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHN
DVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS
LQGFTAAQMGNEAVQQILSE
Ligand information
>6cf6 Chain D (length=10) Species:
9606
(Homo sapiens) [
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ARESSADGAD
Receptor-Ligand Complex Structure
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PDB
6cf6
Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
Resolution
1.93 Å
Binding residue
(original residue number in PDB)
R361 S363 L368 G371 Y372 K393 L396 N401 Y405 H407 D425 W427 F429 E434 R440
Binding residue
(residue number reindexed from 1)
R47 S49 L54 G57 Y58 K79 L82 N87 Y91 H93 D111 W113 F115 E120 R126
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:6cf6
,
PDBe:6cf6
,
PDBj:6cf6
PDBsum
6cf6
PubMed
29604130
UniProt
Q6PFX9
|TNKS1_MOUSE Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=Tnks)
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