Structure of PDB 6cen Chain A Binding Site BS01

Receptor Information
>6cen Chain A (length=226) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENP
CGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGW
GLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD
RIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMEL
TFNYNLDCLGRTECHCGADNCSGFLG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cen Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
Resolution1.61 Å
Binding residue
(original residue number in PDB)		I1188 F1199 M1201 L1202 T1203 T1232 Y1261 N1262 L1263 D1264 C1265
Binding residue
(residue number reindexed from 1)		I131 F142 M144 L145 T146 T175 Y204 N205 L206 D207 C208
Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6cen, PDBe:6cen, PDBj:6cen
PDBsum6cen
PubMed29742153
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

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