Structure of PDB 6c1v Chain A Binding Site BS01

Receptor Information
>6c1v Chain A (length=68) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYL
GNTVDLSSFDFRTGKMMP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6c1v Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		R166 K167 S168 G169 D176 K186 R188
Binding residue
(residue number reindexed from 1)		R19 K20 S21 G22 D29 K39 R41
Binding affinityPDBbind-CN: Kd=13uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6c1v, PDBe:6c1v, PDBj:6c1v
PDBsum6c1v
PubMed29567833
UniProtQ9UBB5|MBD2_HUMAN Methyl-CpG-binding domain protein 2 (Gene Name=MBD2)

[Back to BioLiP]