Structure of PDB 6bz1 Chain A Binding Site BS01

Receptor Information
>6bz1 Chain A (length=89) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSS
NKLFQYASTDMDKVLLKYTEYSEPHESRTNTVILETLKR
Ligand information
Receptor-Ligand Complex Structure
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PDB6bz1 The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		G2 R3 K4 I6 K23 R24 K30 K31
Binding residue
(residue number reindexed from 1)		G1 R2 K3 I5 K22 R23 K29 K30
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0045944 positive regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6bz1, PDBe:6bz1, PDBj:6bz1
PDBsum6bz1
PubMed29477338
UniProtQ02078|MEF2A_HUMAN Myocyte-specific enhancer factor 2A (Gene Name=MEF2A);
Q02080|MEF2B_HUMAN Myocyte-specific enhancer factor 2B (Gene Name=MEF2B)

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