Structure of PDB 6bwy Chain A Binding Site BS01

Receptor Information
>6bwy Chain A (length=344) Species: 9606,284812 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSL
HGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQ
ITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEE
QFALLLNKIWDEQTNHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHN
DTWVKLNQRRGFLANQAPRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSP
CFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRAQEGLRTLAEAGAKISI
MTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bwy Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S78 L79 H80 G81 T82 K83 D84 H106 F108 T131 R133 Y135 Q140 L142 S143 K144 D145
Binding residue
(residue number reindexed from 1)		S49 L50 H51 G52 T53 K54 D55 H77 F79 T102 R104 Y106 Q111 L113 S114 K115 D116
Binding affinityPDBbind-CN: Kd=26uM
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
Cellular Component
GO:0000781 chromosome, telomeric region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bwy, PDBe:6bwy, PDBj:6bwy
PDBsum6bwy
PubMed29596531
UniProtO13988|POT1_SCHPO Protection of telomeres protein 1 (Gene Name=pot1);
Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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