Structure of PDB 6bwb Chain A Binding Site BS01

Receptor Information
>6bwb Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS
Ligand information
>6bwb Chain B (length=26) Species: 928303 (Hendra virus horse/Australia/Hendra/1994) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CLGRRVVQPGMFADYPPTKKARVLLR
Receptor-Ligand Complex Structure
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PDB6bwb Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S100 R103 F133 W137 N141 S144 G145 T150 Q176 W179 N183 G186 D187 W222 R229 W264 T302 R306 V312 T313 G314 D316 T319 E345 W348 N352 E387 W390 S393 N394 I397
Binding residue
(residue number reindexed from 1)		S29 R32 F62 W66 N70 S73 G74 T79 Q105 W108 N112 G115 D116 W151 R158 W193 T231 R235 V241 T242 G243 D245 T248 E274 W277 N281 E316 W319 S322 N323 I326
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bwb, PDBe:6bwb, PDBj:6bwb
PDBsum6bwb
PubMed30209309
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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