Structure of PDB 6bw4 Chain A Binding Site BS01

Receptor Information
>6bw4 Chain A (length=377) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVT
RPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNKIEIEIKINHEGEVNR
ARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKE
GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV
VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL
SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN
ETILASSGTDRRLNVWDLSKIGEEQSEDGPPELLFIHGGHTAKISDFSWN
PNEPWVICSVSEDNIMQVWQMAENIYN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bw4 Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E41 W42 H71 S73 E126 N128 E179 Y181 E231 D248 E395 N397
Binding residue
(residue number reindexed from 1)		E37 W38 H67 S69 E97 N99 E150 Y152 E202 D219 E362 N364
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005515 protein binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0031492 nucleosomal DNA binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006260 DNA replication
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent chromatin assembly
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007420 brain development
GO:0008285 negative regulation of cell population proliferation
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042659 regulation of cell fate specification
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:1902455 negative regulation of stem cell population maintenance
GO:1902459 positive regulation of stem cell population maintenance
GO:2000736 regulation of stem cell differentiation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0016581 NuRD complex
GO:0016589 NURF complex
GO:0032991 protein-containing complex
GO:0033186 CAF-1 complex
GO:0035098 ESC/E(Z) complex
GO:0070822 Sin3-type complex
GO:1904949 ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bw4, PDBe:6bw4, PDBj:6bw4
PDBsum6bw4
PubMed30462309
UniProtQ09028|RBBP4_HUMAN Histone-binding protein RBBP4 (Gene Name=RBBP4)

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