Structure of PDB 6bvh Chain A Binding Site BS01

Receptor Information
>6bvh Chain A (length=223) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN
Ligand information
Receptor-Ligand Complex Structure
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PDB6bvh Potent, multi-target serine protease inhibition achieved by a simplified beta-sheet motif.
Resolution1.927 Å
Binding residue
(original residue number in PDB)		F41 H57 D189 S190 C191 Q192 G193 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		F24 H40 D171 S172 C173 Q174 G175 S177 S192 W193 G194
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 G175 D176 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0097655 serpin family protein binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0097180 serine protease inhibitor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bvh, PDBe:6bvh, PDBj:6bvh
PDBsum6bvh
PubMed30668585
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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