Structure of PDB 6btx Chain A Binding Site BS01

Receptor Information

>6btx Chain A (length=377) Species: 264462 (Bdellovibrio bacteriovorus HD100)

QSLLRIETQLLLGRLLTRSGDQAWDFVVPFALLVIFPGKLQVAAFYYLIV
KIGTFLLTVVKWGVWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFI
ALALSGVMASLGSQITDISVSLVAPEKLTHFNSWLRRIDLATEVGAPILA
GALFAFHPEQLPLAGLFLIGLWNLVSFVPEYFLLRNVISFSDPIFWLILS
YALLWLSVLSPHGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFP
YLVRRLGLISSSRWHLGFQGVTLGIAVTAFAMGSTASVYVFLGCILLSRV
GLYGFSNGEFELRQRLIPEGRRGELNSLSSLTTTSATLILFSAGSLLPQT
EDFKYLVYVSLAAVLLANVVFIKWSSR

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6btx Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6btx Calcium is an essential cofactor for metal efflux by the ferroportin transporter family.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): Q84 N196 E203
• Binding residue (residue number reindexed from 1): Q67 N173 E180
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005381 iron ion transmembrane transporter activity
• GO:0046872 metal ion binding

Biological Process

• GO:0034755 iron ion transmembrane transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6btx, PDBe:6btx, PDBj:6btx
• PDBsum: 6btx
• PubMed: 30082682
• UniProt: Q6MLJ0|FPN_BDEBA Ferreportin (Gene Name=slc39)