Structure of PDB 6bt2 Chain A Binding Site BS01

Receptor Information
>6bt2 Chain A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPPRFQRDFVDLRPPIRVMQWNILAQALGVEALKWEERKCLILEEILAYQ
PDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCA
LFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHL
KARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHF
ASSSLNLNSAYKLLSADGQSEPPYTTWRHTLDYIWYSKHALNVRSALDLL
TPSFNYPSDHLSLVCDFSFT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6bt2 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6bt2 The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Resolution2.411 Å
Binding residue
(original residue number in PDB)		N326 H414
Binding residue
(residue number reindexed from 1)		N189 H260
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.108: nocturnin.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity
Biological Process
GO:0007623 circadian rhythm

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Molecular Function
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Biological Process
External links
PDB RCSB:6bt2, PDBe:6bt2, PDBj:6bt2
PDBsum6bt2
PubMed29860338
UniProtQ9UK39|NOCT_HUMAN Nocturnin (Gene Name=NOCT)

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