Structure of PDB 6bsz Chain A Binding Site BS01

Receptor Information
>6bsz Chain A (length=445) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQI
NKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAKISGVIGAAASSVS
IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI
VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRP
GEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLQQSGHFLWIGSD
SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF
AEFWEENFGCKLKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGR
YDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASE
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain6bsz Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6bsz Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R75 A154 A155 S156 A177 S178 T179 Y227 D309 K401
Binding residue
(residue number reindexed from 1)		R39 A95 A96 S97 A118 S119 T120 Y168 D250 K331
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bsz, PDBe:6bsz, PDBj:6bsz
PDBsum6bsz
PubMed29402739
UniProtO00222|GRM8_HUMAN Metabotropic glutamate receptor 8 (Gene Name=GRM8)

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