Structure of PDB 6bsh Chain A Binding Site BS01

Receptor Information

>6bsh Chain A (length=544) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE))

PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPE
NPYNTPVFRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGD
AYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSS
MTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWG
LTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGK
LNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEP
VHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTN
DVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWVPE
WEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAASRETKLGKAGYVTNKGR
QKVVTLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQYALGIIQAQPDQS
ESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR

Ligand information

>6bsh Chain D (length=23)

gtatgccactagttattgtggcc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bsh Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.
• Resolution: 2.649 Å
• Binding residue (original residue number in PDB): K73 M230 G231 N255 Q258 K259 G262 K263 W266 H361 Q407 R448 T473 N474 Q475 Y501
• Binding residue (residue number reindexed from 1): K60 M217 G218 N242 Q245 K246 G249 K250 W253 H348 Q394 R435 T460 N461 Q462 Y488

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:6bsh, PDBe:6bsh, PDBj:6bsh
• PDBsum: 6bsh
• PubMed: 29295939
• UniProt: P04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)