Structure of PDB 6brx Chain A Binding Site BS01

Receptor Information
>6brx Chain A (length=433) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQ
LRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPI
AVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS
KEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVV
FGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI
LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSL
LFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLC
QELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIF
AIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
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PDB6brx Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R63 E199 K321 G356 I357 G358 V360 T361 R454 K468 T469 R470 A471 T473
Binding residue
(residue number reindexed from 1)		R35 E171 K236 G271 I272 G273 V275 T276 R369 K383 T384 R385 A386 T388
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6brx, PDBe:6brx, PDBj:6brx
PDBsum6brx
PubMed29715472
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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