Structure of PDB 6bkf Chain A Binding Site BS01

Receptor Information
>6bkf Chain A (length=562) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKDVT
DSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLN
YRDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSL
LQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDL
EKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIE
TKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKA
DIQICILDGEMMAYNPNTQTFMQLQTCYCVFDVLMVNNKKLGHETLRKRY
EILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLS
IYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKRGGMMSHFLCAVA
EKPPKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCG
TEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWH
ECMTLDDLEQLR
Ligand information
Receptor-Ligand Complex Structure
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PDB6bkf Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Y82 G83 I84 K85 T87 M88 R278 S292 N294 Y296 Y298
Binding residue
(residue number reindexed from 1)		Y71 G72 I73 K74 T76 M77 R257 S271 N273 Y275 Y277
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkf, PDBe:6bkf, PDBj:6bkf
PDBsum6bkf
PubMed29980672
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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