Structure of PDB 6bir Chain A Binding Site BS01

Receptor Information
>6bir Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFAS
FEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPN
VLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPF
LPSTEDVYDCRVEHWGLDEPLLKHWEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bir The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Q9 E11 A52 S53 F54 G58 N62 V65 N69 I72 R76
Binding residue
(residue number reindexed from 1)		Q6 E8 A49 S50 F51 G55 N59 V62 N66 I69 R73
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6bir, PDBe:6bir, PDBj:6bir
PDBsum6bir
PubMed29317506
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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